Posted February 10th, 2014 in Recent News.
The specific carbohydrate diet (SCD), popular among patients with inflammatory bowel disease (IBD), is associated with distinct changes in the intestinal microbiome, researchers at Rush University have found.
The trademarked SCD, as described by Elaine Gottschall, MSc, in her book, “Breaking the Vicious Cycle” (The Kirkton Press; 2012), is “predicated on the understanding that ulcerative colitis, Crohn’s disease, irritable bowel syndrome and gluten therapy resistant celiac [disease] are the consequence of an overgrowth and imbalance of intestinal microbial flora.”
Ece Mutlu, MD, associate professor of medicine, Rush University Medical Center, Chicago, and her colleagues analyzed fecal samples from 20 patients with IBD who reported following the SCD and 20 patients with IBD who did not adhere to the diet: Each group included 10 patients with Crohn’s disease and 10 patients with ulcerative colitis. Some patients were receiving immunosuppressant medications at the time of fecal sample analysis.
Dr. Mutlu and her team performed 16S rDNA pyrosequencing and found that individuals in the SCD group had greater intestinal bacterial diversity compared with those in the control group, in addition to having a differing microbiome composition. The study was not designed to measure endoscopic and clinical disease activity, but Dr. Mutlu told Gastroenterology & Endoscopy News that she observed symptom relief in some patients following the diet.”